Psychiatry research
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Psychiatry research · Sep 2019
Randomized Controlled TrialProphylactic use of ketamine reduces postpartum depression in Chinese women undergoing cesarean section✰.
This study aimed to explore the effect of prophylactic ketamine administration on postpartum depression in Chinese woman undergoing cesarean section. This randomized controlled study included 654 Chinese women undergoing cesarean section. At 10 min after child birth, patients in the ketamine group were given 0.5 mg/kg ketamine, whereas patients in the control group received standard postpartum care. ⋯ Logistic analysis showed that ketamine administration protected against postpartum depression, and PPD-associated risk factors included stress during pregnancy, antenatal depressive symptom and antenatal suicidal ideation. In addition, the antidepressive effect of prophylactic ketamine was stronger in mothers with a history of moderate stress during pregnancy, antenatal depressive symptom and antenatal suicidal ideation. Our findings suggest that ketamine functions as a prophylactic agent against PPD.
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Psychiatry research · Dec 2018
Randomized Controlled TrialAn evaluation of a low intensity mHealth enhanced mindfulness intervention for Chinese university students: A randomized controlled trial.
Mental disorders and sleep dysfunction are common among Chinese university students. This study aimed to evaluate a low cost scalable mindfulness intervention program to improve psychological health and sleep quality among Chinese university students. A randomized controlled trial with 101 university students (mean age 22.30 ± 2.63, 69.31% female) was conducted. ⋯ After the intervention at week 4, compared to controls, completers in group 2, 3 and 4 (n = 42) showed significantly reduced depression (Cohen's d = 0.83), anxiety (Cohen's d = 0.84), and stress (Cohen's d = 0.75), and improved subjective sleep quality (Cohen's d = 2.00), sleep latency (Cohen's d = 0.55), and habitual sleep efficiency (Cohen's d = 0.86). The effect was maintained at week 7. Low-intensity mindfulness interventions might be a useful intervention program in university settings.
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Psychiatry research · Nov 2018
Randomized Controlled TrialRapid inflammation modulation and antidepressant efficacy of a low-dose ketamine infusion in treatment-resistant depression: A randomized, double-blind control study.
Increasing evidence supports the rapid antidepressant effect of a low-dose ketamine infusion in treatment-resistant depression (TRD). Proinflammatory cytokines play a crucial role in the pathophysiology of TRD. However, it is unknown whether the rapid antidepressant effect of ketamine is related to the rapid suppression of proinflammatory cytokines. ⋯ The decrease in TNF-α between baseline and 40 min postinfusion was positively correlated with a decrease in MADRS scores across time in the 0.5 mg/kg ketamine group. This is the first clinical study to support a positive correlation between changes in cytokine levels after ketamine infusion and improvements in depressive symptoms with TRD. The rapid suppression of proinflammatory cytokines may contribute to the rapid antidepressant effect of the ketamine infusion.
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Psychiatry research · Mar 2018
Randomized Controlled TrialBright light and oxygen therapies decrease delirium risk in critically ill surgical patients by targeting sleep and acid-base disturbances.
This study examined the effects of bright light therapy (BLT) on the incidence of delirium in post-operative patients admitted to a surgical intensive care unit (SICU) and delineates risk and protective factors. We included 62 patients in a single-blind, randomized controlled study. The intervention group was treated with care as usual plus BLT for three consecutive days. ⋯ BLT plus nasal cannula oxygen significantly reduced the likelihood of delirium. BLT significantly lowered ISI scores, while nasal cannula oxygen significantly enhanced bicarbonate levels. The results indicate that BLT and supplementary oxygen therapy may protect against delirium by targeting sleep-wake and deficits in the bicarbonate buffer system.
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Psychiatry research · Nov 2016
Randomized Controlled TrialLanguage and hope in schizophrenia-spectrum disorders.
Hope is integral to recovery for those with schizophrenia. Considering recent advancements in the examination of clients' lexical qualities, we were interested in how clients' words reflect hope. Using computerized lexical analysis, we examined social, emotion, and future words' relations to hope and its pathways and agency components. ⋯ In linear multiple regressions, no LIWC variable significantly predicted hope agency, but anger words significantly predicted both total hope and hope pathways. Our findings indicate lexical analysis tools can be used to investigate recovery-oriented concepts such as hope, and results may inform clinical practice. Future research should aim to replicate our findings in larger samples.