Journal of periodontology
-
Journal of periodontology · Jul 2014
Comparative StudySalivary interleukin-6 and -8 in patients with oral cancer and patients with chronic oral inflammatory diseases.
Previous research has indicated that salivary interleukin (IL)-6 and IL-8 are potential biomarkers for oral squamous cell carcinoma (OSCC). However, their levels have been found to be significantly elevated in patients with chronic periodontitis (CP) or oral lichen planus (OLP). The data also showed wide variations in levels among the different studies, and no standardization procedure was ever performed. Therefore, the objective of this study is to determine whether CP or OLP confounds the use of IL-6 or IL-8 for OSCC detection. ⋯ Salivary IL-6 may be a useful biomarker in the detection of OSCC, unconfounded by CP or OLP.