Archives of dermatological research
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Arch. Dermatol. Res. · Jan 1992
Evaluation of cutaneous algogenic responses to bradykinin and inhibition by bradykinin analogs.
Bradykinin has long been postulated to have a major role in physiologic human pain production. We have developed a method to systematically quantify the algogenic response to bradykinin in human skin by the direct application of bradykinin to suction blister bases. ⋯ This result could not be predicted on the basis of inhibition of bradykinin binding to its guinea-pig ileum receptor or to previous studies of bradykinin-induced pain production in animal models. This peptide may have an eventual role as a physiologic pain inhibitor.