AJNR. American journal of neuroradiology
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AJNR Am J Neuroradiol · Jan 1995
Comparative StudyMagnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and nonenhanced T1-weighted images.
To define the relationship between magnetization transfer and blood-brain-barrier breakdown in multiple sclerosis lesions using gadolinium enhancement as an index of the latter. ⋯ We speculate that diminished MTR may reflect diminished myelin content and that hypointensity on T1-weighted images corresponds to demyelination. Central regions of ring-enhancing lesions had a lower MTR than the periphery, suggesting that demyelination in multiple sclerosis lesions occurs centrifugally. In addition, the short-repetition-time pulse sequence seems useful in the evaluation of myelin loss in patients with multiple sclerosis.
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AJNR Am J Neuroradiol · Jan 1995
Clinical, neurodiagnostic, and MR findings in children with spinal and brain stem multiple sclerosis.
To describe the clinical, neurodiagnostic, and MR findings in seven children with brain stem and spinal multiple sclerosis. ⋯ Multiple sclerosis involvement of the brain stem and spinal cord may be associated with extensive swelling and MR signal changes suggestive of neoplasm without typical cerebral white matter abnormalities. Serial clinical and neuroimaging examinations may be necessary to make a definitive diagnosis of multiple sclerosis in children.