AJNR. American journal of neuroradiology
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AJNR Am J Neuroradiol · Aug 2012
Comparative StudyRelationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma.
Both IDH1 mutation and MGMT promoter methylation are associated with longer survival. We investigated the ability of imaging correlates to serve as noninvasive biomarkers for these molecularly defined GBM subtypes. ⋯ Imaging features are potentially predictive of IDH1 mutational status but were poorly correlated with MGMT promoter methylation. Edema stratifies survival in MGMT promoter methylated but not in unmethylated tumors; patients with methylated tumors with little or no edema have particularly long survival.
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AJNR Am J Neuroradiol · Aug 2012
ReviewChallenges of the anatomy and diffusion tensor tractography of the Meyer loop.
This review addresses the complex and often controversial anatomy of the anterior bundle of the OR, also known as the Meyer loop. Before the advent of MR imaging, 2 main types of studies attempted to ascertain the "safe" distance for anterior temporal lobe resection to avoid postsurgical VFDs. ⋯ Although many of these techniques are still experimental, there are some clinical situations for which they may prove to be very helpful if properly performed and validated. The motivation for this review was to improve the outcome of patients with TLE undergoing temporal lobectomy: Would having anatomic information about the OR available to the neurosurgeon decrease the risk of postsurgical VFDs?
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AJNR Am J Neuroradiol · Aug 2012
Case ReportsAtypical diffusion-restricted lesion in 5-Fluorouracil encephalopathy.
Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging.
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AJNR Am J Neuroradiol · Aug 2012
CT fluoroscopy-guided cervical interlaminar steroid injections: safety, technique, and radiation dose parameters.
Cervical epidural steroid injections are approached with trepidation because of concerns over safety, including direct spinal cord injury. CT fluoroscopy is an alternative to conventional fluoroscopy that could potentially help reduce the risk of injury by providing improved localization of the needle tip. We sought to determine rates of technical success and risk of complications in our initial cohort of patients treated with cervical interlaminar ESI performed under CTF guidance. ⋯ CTF-guided cervical interlaminar ESI can be performed at all levels in the cervical spine with a low rate of procedural complications. Short total procedure times, CT-fluoroscopy times, and reduced tube current make this procedure a practical alternative to cervical ESI performed under conventional fluoroscopy.
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AJNR Am J Neuroradiol · Aug 2012
Active bleeding in acute subarachnoid hemorrhage observed by multiphase dynamic-enhanced CT.
Acute SAH is reportedly associated with rebleeding from aneurysms, and recent advances in imaging technology allow us to visualize active bleeding in SAH cases. This study aimed to retrospectively investigate the incidence and characteristics of active bleeding in patients with spontaneous SAH by using multiphase dynamic-enhanced CT. ⋯ A high incidence of active bleeding (25.5%) was detected by multiphase dynamic-enhanced CT in patients with acute SAH. These results indicate that an awareness of active bleeding in patients with SAH has the potential to affect the treatment strategy.