European heart journal
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European heart journal · Aug 2008
Review Meta AnalysisAutologous bone marrow stem cells to treat acute myocardial infarction: a systematic review.
To provide systematic assessment of the safety and efficacy of autologous bone marrow-derived stem cell (BMSC) transplantation in acute myocardial infarction (AMI) based on clinical evidence. ⋯ Stem cell treatment for AMI still holds promise. Clinically, these data suggest that improvement over conventional therapy can be achieved. Further, adequately powered trials using optimal dosing, longer term outcome assessments, more reliable, and more patient-centred outcomes are required.