Lasers in surgery and medicine
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A human glioma spheroid model is used to investigate the efficacy of different light delivery schemes in 5-aminolevulinic acid (ALA)--mediated photodynamic therapy (PDT). The results provide the rationale for the development of an indwelling balloon applicator for optimizing light delivery. ⋯ The results of the in vitro studies support the development of an indwelling balloon applicator for the delivery of light doses in long term multi-fractionated PDT regimens.
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Providing general anesthesia in an office-based setting can be time consuming, risky, and expensive. The purpose of this study was to describe a technique for total intravenous anesthesia (TIVA) technique that can be easily utilized by anesthesiologists in an office-based setting for laser facial resurfacing. ⋯ TIVA is an excellent method for providing anesthesia for laser facial resurfacing in an office-based setting.
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The prognosis of patients suffering from laryngeal carcinomas can be improved by early diagnosis. Exact demarcation of tumor margins could contribute to an optimum preservation of the larynx. Therefore, the aim of the present study was the evaluation of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PPIX) fluorescence as a new diagnostic procedure for the detection of laryngeal cancer. ⋯ According to these preliminary results, the presented method seems to be a promising adjunct diagnostic procedure for the early identification of malignant neoplasms in the larynx. The aim of further investigations is the assessment of sensitivity and specificity and an evaluation of fluorescence-guided laser resections of laryngeal cancer. Lasers Med. Surg. 25:414-420, 1999.
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Traumatic transection of a peripheral nerve is inherently associated with the development of neuroma at the end of the proximal stump, often leading to therapy-resistant pain. This study was designed to evaluate whether the neodymium:yttrium aluminum garnet (Nd:YAG) laser could prevent neuroma formation after neurectomy. ⋯ Within the limitations of this study it is concluded that the formation of amputation neuromas is suppressed by Nd:YAG laser application by thermal coagulation of the nerve and suppression of Schwann-cell proliferation.
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Comparative Study Clinical Trial
Evaluation of topical anesthetics by laser-induced sensation: comparison of EMLA 5% cream and 40% lidocaine in an acid mantle ointment.
Current techniques for assessing local anesthetics (e.g., pin-prick test) cannot elicit a specific afferent activity without contamination from mechanosensitive receptors. This study was aimed to validate the use of non-scarring laser pulses as a reproducible method to assess effectiveness of topical anesthetics by comparing EMLA 5% cream and 40% lidocaine ointment. ⋯ Non-scarring laser pulses are reliable and reproductive pain inducers for assessing topical anesthetics showing a low intra-individual variation. This technique demonstrated that EMLA 5% cream is significantly more effective than 40% lidocaine ointment.