Scandinavian journal of rheumatology
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Scand. J. Rheumatol. · Jan 1983
Randomized Controlled Trial Comparative Study Clinical TrialComparison of three slow-release acetylsalicylic acid preparations in rheumatoid arthritis.
Nine patients suffering from chronic rheumatoid arthritis were each given single doses of 1 g acetylsalicylic acid, in the form of each of the preparations studied: an enteric-coated tablet, a microcrystalline tablet, and a capsule containing enterosoluble granules. Absorption from each preparation was good in all patients. Onset of absorption varied to some degree, but similar salicylate levels were reached within 5 hours with all preparations. In the case of enteric-coated tablets, relatively high salicylate levels persisted 12 hours after dosing, which would seem to permit twice daily dosage, regardless of the total daily dose.
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Scand. J. Rheumatol. · Jan 1981
Comparative Study Clinical Trial Controlled Clinical TrialComparison of serum salicylate levels and gastro-intestinal blood loss between salsalate (Disalcid)and other forms of salicylates.
In a first stage the effect of a single dose of 3 g of salsalate on serum salicylate level was compared with a single intake of 3 g of soluble or enteric-coated acetylsalicylates in 12 healthy subjects. Salsalate seems to resorb faster than the enteric-coated forms but more slowly than the soluble forms of acetylsalicylate. ⋯ The ideal dosage to obtain a serum salicylate level of 20 mg/100 ml seems to lie between 3 and 4 g of salsalate a day. Salsalate caused abnormal gastro-intestinal blood loss in only 2 of the 42 patients studied, which is significantly fewer compared with the soluble, intravenous or enteric-coated forms of acetylsalicylates.
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A new experimental design was developed to study the value of clinical parameters of disease activity in patients with rheumatoid arthritis. Ten patients with classical rheumatoid arthritis were examined by five senior doctors in a department of medical rheumatology. ⋯ The variation from morning to afternoon and from day to day was negligible. It is concluded that registration of elaborated articular scores is useless in the daily routine in rheumatological departments when different doctors examine the patients.