American journal of industrial medicine
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A discussion of the history of substitutions in industrial solvent use is presented, and animal carcinogenicity studies with certain chlorinated hydrocarbon solvents are reviewed. The present knowledge on the association between occupational exposure to chlorinated hydrocarbon solvents and human carcinogenicity is summarized, including a critical review of 23 studies pertaining to human carcinogenicity. ⋯ The literature supports an association between occupational exposures to chlorinated hydrocarbons and elevated risks of leukemia, lymphoma, and urinary tract cancer. Parental occupational exposures are consistently associated with an elevated childhood cancer risk in the offspring.