The Prostate

The most recent articles from: February 2007

  • The Prostate · Feb 2007

    Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy.

    Certain cancers depend for growth on uptake of cystine/cysteine from their environment. Here we examined advanced human prostate cancer cell lines, DU-145 and PC-3, for dependence on extracellular cystine and sensitivity to sulfasalazine (SASP), a potent inhibitor of the x(c)(-) cystine transporter. ⋯ SASP-induced cystine/cysteine starvation leading to glutathione depletion may be useful for therapy of prostate cancers dependent on extracellular cystine.

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