Anticancer research
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Anticancer research · Jun 2012
ReviewFunctional design of chimeric T-cell antigen receptors for adoptive immunotherapy of cancer: architecture and outcomes.
Adoptive immunotherapy using genetically modified T-cells with a chimeric antigen receptor (CAR) is a promising modality for cancer treatment, because the CAR-grafted T-cells can directly recognize and kill tumor cells, expressing a specific tumor-associated antigen (TAA), in a human leukocyte antigen (HLA)-independent manner. Optimal molecular designs of the CAR and a careful choice of the target TAA are requisite to attain a significant response in CAR-mediated therapy. This review provides a brief overview of the past studies and the present state of CAR research, especially focusing on the development of the CAR protein architecture.
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Anticancer research · May 2012
Clinical TrialPilot study of duloxetine for cancer patients with neuropathic pain non-responsive to pregabalin.
Neuropathic pain frequently occurs in cancer patients, but no drug therapy has been established for this type of disorder. The purpose of this study was to investigate the effect of duloxetine in cancer patients suffering from neuropathic pain. ⋯ Duloxetine administration may be effective for neuropathic pain in cancer patients who cannot tolerate pregabalin administration.
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Anticancer research · May 2012
Parenteral nutrition support for patients with pancreatic cancer--improvement of the nutritional status and the therapeutic outcome.
Malnutrition is a frequent and serious problem of patients with pancreatic cancer (i.e. due to exocrine pancreatic insufficiency, postoperative syndromes, anorexia, chemotherapy, and/or tumor progression). In many cases it has negative effects on the quality of life or on the tumor therapy. We investigated if malnutrition can be resolved or corrected by adequate home parenteral nutrition (PN) of pancreatic cancer (PaCa) patients, in cases where dietary advice and oral nutrition supplementation failed to correct the deficiencies. The energy supply via PN was analyzed in patients with PaCa, with focus on the single components in compounded PN. ⋯ A timely onset of PN with sufficient calories leads to an improved nutritional status of patients with PaCa disease. PN enhances the quality of life, the administration of tumor therapy without interruption and therefore may lead to a better success of the entire therapy. For late-stage tumor patients (Gr2) the quality of life can, at least, be improved. The success of PN is significantly dependent upon the patients' compliance, which could be achieved through intensive consulting and support of all patients and their relatives.
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Anticancer research · Apr 2012
Adjuvant intravesical instillation for primary T1G3 bladder cancer: BCG versus MMC in Korea.
To compare the efficacy of bacillus Calmette-Guerin (BCG) and mitomycin-C (MMC) intravesical instillation for primary T1G3 bladder cancer (BC). ⋯ There were no statistically significant differences regarding recurrence and disease progression rate at the time of recurrence between the two adjuvant treatments in primary T1G3 BC. Thus, large prospective studies in Asian population are required.
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Anticancer research · Feb 2012
The effect of radiotherapy on implant-based breast reconstruction in the setting of skin-sparing mastectomy: clinical series and review of complications.
With the increasing popularity of skin-sparing mastectomy techniques, implant-based breast reconstruction and use of perioperative radiation therapy, there is a growing need to scrutinize the effects they have on breast reconstruction. This study examined the effect of radiation on implant-based breast reconstruction in patients who had skin-sparing or conventional mastectomies in terms of complication, reoperation, and capsular contracture rates. ⋯ The results of this study were more favourable than those of similar studies reported in the current literature, suggesting an increased role for implant-based reconstruction in the setting of adjuvant radiotherapy for patients that undergo skin-sparing mastectomy.