Current eye research
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Current eye research · Jul 2008
Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro.
To investigate the effect of tetrandrine on activation of human subconjunctival fibroblasts (SCFs) in vitro. ⋯ Tetrandrine suppresses Smad2 signal and fibrogenic responses in SCFs in association with Smad7 up-regulation, suggesting its potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation.