Prenatal diagnosis
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In pediatrics, anogenital distance (AGD) serves as a bioassay of normal phenotypic androgen action on the external genitalia. Recently, hypospadias and cryptorchidism were reported to be associated with reduced AGD. No normal reference ranges exist for fetuses throughout gestation. This study defines the normal centile chart of the AGD, in male and female fetuses, between 20 and 35 weeks of gestation. ⋯ AGD measurement in utero is feasible. These measurements assess the normality of the perineal region and may assist in the detection of genital anomalies.