Kidney international
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Kidney international · Apr 1991
Comparative Study Clinical Trial Controlled Clinical TrialEffect of dialysate and substitution fluid buffer on buffer flux in hemodiafiltration.
The effect of differing dialysate and substitution fluid buffer types and concentrations on acid-base balance have not been assessed in patients treated with hemodiafiltration for ESRD. To determine bicarbonate, acetate, lactate and total buffer flux, mass balance studies were performed in patients treated with hemodiafiltration using four different combinations of dialysate and substitution fluids. Driving force for bicarbonate flux was assessed in all treatments. ⋯ Overall buffer flux depended on the bicarbonate driving force, ultrafiltration rate, and varied with the type of substitution and dialysate buffer employed. The types and concentrations of buffer used in dialysate and substitution fluid have important effects on the acid-base balance of patients treated with hemodiafiltration. The long-term implications of different therapeutical choices in these patients is unknown.