Kidney international
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Kidney international · Jun 1999
Randomized Controlled Trial Multicenter Study Clinical TrialMulticenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure.
Patients with acute renal failure (ARF) have high morbidity and mortality rates, particularly if they have serious comorbid conditions. Several studies indicate that in rats with ARF caused by ischemia or certain nephrotoxins, insulin-like growth factor-I (IGF-I) enhances the recovery of renal function and suppresses protein catabolism. ⋯ rhIGF-I does not accelerate the recovery of renal function in ARF patients with substantial comorbidity.