Kidney international
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Kidney international · Apr 2000
Randomized Controlled Trial Multicenter Study Clinical TrialExacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism.
Endothelin is a potent vasoconstrictor that has been implicated in the pathogenesis of radiocontrast nephrotoxicity. Endothelin antagonists may reduce the renal hemodynamic abnormalities following radiocontrast administration. ⋯ In patients with chronic renal insufficiency who were undergoing cardiac angiography, endothelin receptor antagonism with SB 209670 and intravenous hydration exacerbate radiocontrast nephrotoxicity compared with hydration alone.