Kidney international
-
Kidney international · Nov 2003
Disease progression and outcomes in chronic kidney disease and renal transplantation.
It is unknown whether renal transplant recipients (RTR) have better outcomes and disease progression rates compared to patients with chronic kidney disease (CKD) when matched for the level of kidney function. ⋯ RTR had similar mortality rates compared to patients with CKD despite enjoying slower rates of disease progression and better kidney survival rates. These data suggest that RTR are a unique subset of patients with CKD whose comorbid conditions likely offset the potential benefits of slower rates of progression.
-
Kidney international · Nov 2003
Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice.
Sepsis is a common cause of acute renal failure (ARF). The incidence of sepsis increases dramatically after 50 years of age; however, most ARF studies are performed in young mice. ⋯ CLP in aged mice causes functional and histologic changes consistent with human ARF. A single dose of ethyl pyruvate inhibits renal and multiple organ damage, and is still effective when given 12 hours after surgery.
-
Kidney international · Nov 2003
Biography Historical ArticlePresentation of the 2003 Jean Hamburger Award to Robert W. Schrier.