Kidney international
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Kidney international · Jun 2005
Randomized Controlled Trial Comparative Study Clinical TrialRegional citrate versus systemic heparin anticoagulation for continuous renal replacement in critically ill patients.
We determined the effect of regional citrate versus systemic heparin anticoagulation for continuous renal replacement therapy in critically ill subjects suffering from acute renal failure who were not at high risk for hemorrhagic complications. ⋯ Compared with systemic heparin anticoagulation, regional citrate anticoagulation significantly increases hemofilter survival time, and significantly decreases bleeding risk in critically ill patients suffering from acute renal failure and requiring continuous renal replacement therapy.
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Kidney international · Jun 2005
Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD).
The majority of patients with chronic kidney disease (CKD) have excessive vascular calcification; however, most studies demonstrate that a subset of CKD patients do not have, nor develop, vascular calcification despite similar exposure to the uremic environment. This suggests protective mechanisms, or naturally occurring inhibitors, of calcification may be important. ⋯ These data demonstrate that fetuin-A, OPG, and MGP play an important role in the pathogenesis of uremic vascular calcification.