Pharmacotherapy
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of anticoagulant effects and safety of argatroban and heparin in healthy subjects.
To evaluate and compare the relationship between dosage and coagulation parameters, as well as safety profiles, of ascending bolus and infusion dosages of argatroban versus heparin in three phase I studies. ⋯ Anticoagulation was more predictable with argatroban than with heparin as measured by ACT and aPTT, with comparable safety profiles.