Pharmacotherapy
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Clinical Trial
Reteplase for dysfunctional hemodialysis catheter clearance.
To evaluate the efficacy of reteplase administration in clearing hemodialysis catheters. ⋯ Reteplase installation in dysfunctional hemodialysis catheters was effective in restoring catheter function in 87% of episodes. A dose of 1 U appears to be as effective as 4 and 6 U.
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Review Case Reports
Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.
A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium. When both drugs were discontinued, his fever and rigidity subsided and biochemical irregularities spontaneously returned to normal, without any complications. ⋯ Concomitant administration of lithium with olanzapine may place patients at risk for NMS. Clinicians need to be aware of this rare but potentially fatal side effect in patients of all ages, and especially in adolescents receiving both drugs.