Pharmacotherapy
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Clinical Trial
Predictors of hospital mortality for patients with severe sepsis treated with Drotrecogin alfa (activated).
To identify predictors of hospital mortality among patients with severe sepsis who were treated with drotrecogin alfa (activated). ⋯ Number of acquired organ-system derangements, vasopressin administration, and treatment with an inappropriate initial antimicrobial regimen are independently associated with an increased risk of hospital mortality among patients treated with drotrecogin alfa (activated) for severe sepsis. These findings suggest that other specific medical interventions may increase survival in this patient population.