Pharmacotherapy
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To determine if the uncorrected QT interval (QT(u)) more accurately predicts drug-induced torsade de pointes than QT intervals corrected using the Bazett's (QT(B)), Fridericia (QT(Frid)), or Framingham (QT(Fram)) methods. ⋯ Compared with QT(B) and QT(Frid), the QT(u) and QT(Fram) best predicted haloperidol-induced torsade de pointes in critically ill patients; the QT(Fram) offered no advantage over the QT(u).
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The Food and Drug Administration recently advocated the use of acuity scoring to determine those patients whose mortality benefits outweigh risks of adverse effects from drotrecogin alfa (activated). Many institutions have adopted an Acute Physiology and Chronic Health Evaluation (APACHE) II cutoff score of 25 (i.e., if > or = 25, administer the agent) as a component in determining eligibility for treatment with this agent. Concern is increasing that errors in the acquisition of APACHE scores can lead to prescribing errors with drotrecogin alfa (activated). ⋯ Caution must be used in applying results of APACHE II scores estimated by only one trained individual when deciding to administer or withhold drotrecogin alfa (activated).
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Mechanical ventilation is an integral part of the critical care environment and requires orchestration by a multidisciplinary team of clinicians to optimize therapeutic outcomes. By tradition, pharmacists have not been included on this team since this therapeutic modality is not considered relevant to their scope of practice. ⋯ Pharmacists able to understand and integrate mechanical ventilation with the pharmacotherapeutic needs of patients are better qualified practitioners. The goal of this article is to help clinical pharmacists better understand the complexities of mechanical ventilation and to apply this information in optimizing delivery of pharmaceutical agents to critical care patients.