Pharmacotherapy
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Evaluation of the safety and efficacy of ketorolac versus morphine by patient-controlled analgesia for postoperative pain.
To compare ketorolac tromethamine with morphine for pain management after major abdominal surgery. ⋯ Ketorolac may be effective when administered by PCA device, and has a clear morphine-sparing effect.
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Randomized Controlled Trial Comparative Study Clinical Trial
Pharmacoeconomic analysis of sevoflurane versus isoflurane anesthesia in elective ambulatory surgery.
This study investigated the economic aspects of sevoflurane and isoflurane anesthesia in 47 healthy women undergoing elective ambulatory surgery, as part of a randomized, prospective clinical trial. Patient records were analyzed for anesthetic; duration of surgery, anesthesia, and recovery room stay; and associated charges. ⋯ A minor decrease in recovery room charges ($15) associated with earlier discharge was observed with sevoflurane (p>0.05), but the agent was not associated with lower hospital charges. Larger trials and assessment of other patient populations may show sevoflurane to be more pharmacoeconomically advantageous than isoflurane.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Antianginal response to once-daily diltiazem CD in patients receiving concomitant beta-blockers, long-acting nitrates, or both. Diltiazem CD Study Group.
To determine the safety and efficacy of diltiazem CD 180 mg administered once/day in patients with chronic stable angina inadequately controlled with P-blockers, long-acting nitrates, or both. ⋯ Diltiazem CD 180 mg once/day is an effective, safe, and beneficial initial dosage when added to existing antianginal therapy.
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Randomized Controlled Trial Comparative Study Clinical Trial
Recovery parameters after sevoflurane and isoflurane anesthesia.
We compared recovery times in patients with American Society of Anesthesiologists physical status I-III receiving sevoflurane or isoflurane during surgical procedures longer than 1 hour in duration. Of the 50 patients enrolled, 23 received sevoflurane and 27 received isoflurane. Anesthetic gases were discontinued abruptly at the end of the surgical procedure. ⋯ The time to emergence was significantly less with sevoflurane than with isoflurane (5.6 vs 11.2 min, respectively). There were no significant differences in time to extubation, response to verbal command, or orientation between the groups. Our data support more rapid emergence with sevoflurane than with isoflurane in surgical procedures longer than 1 hour in duration.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
High-dose versus standard-dose epinephrine treatment of cardiac arrest after failure of standard therapy.
To assess the efficacy of high-dose epinephrine (HDE) compared with standard-dose epinephrine (SDE) in emergency department patients in cardiac arrest after SDE failed to improve asystole or ventricular fibrillation. ⋯ Our results are similar to those of controlled clinical trials comparing HDE with SDE in cardiac arrest.