Annals of clinical biochemistry

The most recent articles from: January 2013

  • Ann. Clin. Biochem. · Jan 2013

    Multicenter Study

    Interference of ethylene glycol with (L)-lactate measurement is assay-dependent.

    Metabolites of ethylene glycol (EG) can cross-react in l-lactate assays, leading to falsely elevated serum lactate levels in case of EG intoxication. In this study, we evaluated the effects of EG and its metabolites on routinely used lactate measuring methods. ⋯ The EG metabolites glycolate and glyoxylic acid were shown to falsely elevate l-lactate results with most of the currently used methods due to cross-reactivity with the oxidase enzyme. Falsely elevated l-lactate results can lead to misdiagnosis and inappropriate management of patients with EG intoxication.

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