Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas
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Braz. J. Med. Biol. Res. · Jan 1989
Randomized Controlled Trial Comparative Study Clinical TrialPerspectives on clinical trials for hypertonic saline/dextran solutions for the treatment of traumatic shock.
Animal studies with hypertonic solutions suggest that they can achieve resuscitation of hypovolemic shock with extremely small volumes. Such small volume resuscitation might be ideal in the field treatment of injured patients. ⋯ The solutions have been safe, and we have encountered no adverse side effects from their use. Survival rates to date favor use of the solutions, but we do not have convincing statistical significance yet in that regard.
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Braz. J. Med. Biol. Res. · Jan 1989
Train-of-four as an index of neuromuscular block in cats: changes induced by atropine.
1. The present study reevaluates the effect of atropine on the rate of recovery from tetanic fade caused by intraarterial administration of neostigmine or antinicotinic agents in cat anterior tibial muscle preparations submitted to a train-of-four (TOF) pattern of nerve stimulation. The study also compares the sensitivity of the TOF and tetanic responses as indices of residual nondepolarizing block. 2. ⋯ Both single and TOF twitches were increased by neostigmine and depressed by the antinicotinic agents. 3. Prior administration of atropine reduced the TOF fade induced by the antinicotinic drugs but potentiated that caused by anticholinesterase drugs. 4. These results indicate that TOF fade is not the most sensitive index for studying neuromuscular blockade when drugs other than neuromuscular blockers are also present.
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Braz. J. Med. Biol. Res. · Jan 1989
Cerebral blood flow following hypertonic saline resuscitation in an experimental model of hemorrhagic shock and head injury.
Hypertonic (3.0%) saline (HS) resuscitation from hemorrhagic shock is associated with less cerebral edema and lower intracranial pressure (ICP) compared to normal saline (NS) and 10% Dextran 40 (D-40). The effect of HS resuscitation on cerebral blood flow (CBF) is unknown. Beagle dogs with a head injury underwent shock and resuscitation, receiving either NS (N = 6), HS (N = 6), or D-40 (N = 6). ⋯ Global and hemispheric CBF values were not different between groups at times measured. ICP was significantly lower in animals receiving HS. Therefore, lower ICP following HS resuscitation is not associated with alteration in CBF.