Veterinary surgery : VS
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Veterinary surgery : VS · Mar 1998
Randomized Controlled Trial Comparative Study Clinical TrialComparison of plasma fentanyl concentrations by using three transdermal fentanyl patch sizes in dogs.
To compare plasma fentanyl concentrations attained after the application of three transdermal fentanyl patch sizes (50, 75, and 100 micrograms/hour) in dogs. ⋯ Because of the interindividual and intraindividual variation in plasma fentanyl concentrations, patches should be applied 24 hours before the anticipated time that analgesia will be required. Adequacy of analgesia and potentially deleterious side effects, such as sedation and respiratory depression, should be monitored while the patches are in place. Skin reactions may occur, and the patches should be removed if such skin irritation is seen. After the patch is removed, it is expected that analgesia will wane rapidly because of the brief elimination half-life.