International journal of cardiology
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Overlapping features among aortitides are relatively common although the underlining etiologies may differ. Thus, the clinical classification of aortitides is rather difficult and often misleading. Furthermore, morphologic characterizations of these vascular disorders are frequently overlapping and therefore additional clinical and radiologic information is usually required. The greater challenge is aortitides is whether the initiation is due to an exogenous stimulus or due to an autoantigen.
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Prompt treatment with thrombolytic therapy in acute myocardial infarction has been proven to reduce infarct size and mortality. However, reperfusion fails to occur in 30-50% of patients, either due to impaired epicardial artery flow or microvascular occlusion, with these patients experiencing a higher morbidity and mortality. We review the diagnosis and management of failed thrombolysis in acute myocardial infarction.