International journal of cardiology
-
Meta Analysis
Levosimendan for the treatment of acute severe heart failure: a meta-analysis of randomised controlled trials.
The objective of this study was to critically review the literature to evaluate whether levosimendan compared to standard therapy, in patients with acute severe heart failure, is associated with improved clinical outcomes. ⋯ Levosimendan improved haemodynamic parameters when compared with placebo, without showing evidence of survival benefit. Levosimendan improved both haemodynamics and survival when compared with dobutamine.