Cephalalgia : an international journal of headache
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Randomized Controlled Trial
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.
The C677T variant in the methylenetetrahydrofolate reductase ( MTHFR ; EC 1.5.1.20) enzyme, a key player in the folate metabolic pathway, has been associated with increased risk of migraine with aura. Other genes encoding molecular components of this pathway include methionine synthase ( MTR ; EC 2.1.1.13) and methionine synthase reductase ( MTRR ; EC 2.1.1.135) among others. We performed a haplotype analysis of migraine risk and MTHFR , MTR , and MTRR . ⋯ These results suggest that MTRR variants may protect against migraine with aura in an older population.