Cephalalgia : an international journal of headache
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The aim of this article is to determine the patient-level factors associated with headache neuroimaging in outpatient practice. ⋯ Neuroimaging is routinely ordered in outpatient headache patients including populations where guidelines specifically recommend against their use (migraines, chronic headaches, no red flags).
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Air pollution is linked to increased emergency room visits for headache, and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood. We previously reported that nasal administration of environmental irritants acutely increases meningeal blood flow via a TRPA1-dependent mechanism involving the trigeminovascular system. Here, we examine whether chronic environmental irritant exposure sensitizes the trigeminovascular system. ⋯ These results suggest trigeminovascular sensitization as a mechanism for enhanced headache susceptibility after chemical exposure.
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The objective of this study was to estimate and to characterize the actual patterns of triptan use and overuse in France using a drug reimbursement database. ⋯ This work suggests that triptan overuse may be due to insufficient prescriber awareness of appropriate prescribing. The off-label prescription of triptans among the elderly necessitates investigating their cardiovascular risk profile in this sub-group.