Cephalalgia : an international journal of headache
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Randomized Controlled Trial
Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan.
Endpoints used to evaluate the efficacy of acute anti-migraine drugs do not measure the tolerability. Sustained pain-free response with no adverse events has been recommended as a composite endpoint which measures the efficacy and tolerability attributes that patients desire. ⋯ Composite efficacy-plus-tolerability endpoints may be useful for facilitating comparisons between treatments.
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Randomized Controlled Trial Multicenter Study
Topiramate intervention to prevent transformation of episodic migraine: the topiramate INTREPID study.
The study sought to evaluate whether topiramate prevents development of chronic daily headache (CDH, ≥15 headache days per month) in adult subjects with high-frequency episodic migraine (HFEM, 9-14 migraine headache days/month). A secondary objective was to assess the efficacy of topiramate as preventive migraine treatment in this population. ⋯ Topiramate 100 mg/day did not prevent the development of CDH at six months in subjects with HFEM. Topiramate was effective in reducing headache days and migraine headache days and generally well tolerated.
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Randomized Controlled Trial Multicenter Study
Almotriptan 12.5 mg in menstrually related migraine: a randomized, double-blind, placebo-controlled study.
Menstrually related migraine (MRM) affects more than half of female migraineurs. Because such migraines are often predictable, they provide a suitable target for treatment in the mild pain phase. The present study was designed to provide prospective data on the efficacy of almotriptan for treatment of MRM. ⋯ Almotriptan was significantly more effective than placebo in women with MRM attacks, with consistent efficacy in longer-term follow-up.
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Randomized Controlled Trial Multicenter Study Comparative Study
Effectiveness of manual therapy for chronic tension-type headache: a pragmatic, randomised, clinical trial.
To evaluate the effectiveness of manual therapy (MT) in participants with chronic tension-type headache (CTTH). ⋯ Manual therapy is more effective than usual GP care in the short- and longer term in reducing symptoms of CTTH. Dutch Trial Registration no. TR 1074.
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Randomized Controlled Trial Multicenter Study
Osmophobia in migraine classification: a multicentre study in juvenile patients.
This study was planned to investigate the diagnostic utility of osmophobia as criterion for migraine without aura (MO) as proposed in the Appendix (A1.1) of the International Classification of Headache Disorders (ICHD-II, 2004). ⋯ In conclusion, this study demonstrates that this new approach, proposed in the Appendix (A1.1), appears easy to apply and should improve the diagnostic standard of ICHD-II in young patients too.