Cephalalgia : an international journal of headache
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The purpose of this study was to assess psychometric properties of the six-item Headache Impact Text (HIT-6™) across episodic and chronic migraine. ⋯ Results from these analyses confirm that the HIT-6 is a reliable and valid tool for discriminating headache impact across episodic and chronic migraine.
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Randomized Controlled Trial Multicenter Study
Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study.
Medically intractable chronic migraine (CM) is a disabling illness characterized by headache ≥15 days per month. ⋯ The results of this feasibility study offer promise and should prompt further controlled studies of ONS in CM.
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Randomized Controlled Trial
Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan.
Endpoints used to evaluate the efficacy of acute anti-migraine drugs do not measure the tolerability. Sustained pain-free response with no adverse events has been recommended as a composite endpoint which measures the efficacy and tolerability attributes that patients desire. ⋯ Composite efficacy-plus-tolerability endpoints may be useful for facilitating comparisons between treatments.
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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) shares common symptoms with migraine. Most CADASIL causative mutations occur in exons 3 and 4 of the Notch 3 gene. This study investigated the role of C381T (rs 3815188) and G684A (rs 1043994) single nucleotide polymorphisms (SNP) in exons 3 and 4, respectively, of the Notch 3 gene in migraine. ⋯ Further investigation of the G684A variant and the Notch 3 gene is warranted to understand their role in migraine.