Cephalalgia : an international journal of headache
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Randomized Controlled Trial Multicenter Study
Occipital nerve stimulation for the treatment of intractable chronic migraine headache: ONSTIM feasibility study.
Medically intractable chronic migraine (CM) is a disabling illness characterized by headache ≥15 days per month. ⋯ The results of this feasibility study offer promise and should prompt further controlled studies of ONS in CM.
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Randomized Controlled Trial
Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan.
Endpoints used to evaluate the efficacy of acute anti-migraine drugs do not measure the tolerability. Sustained pain-free response with no adverse events has been recommended as a composite endpoint which measures the efficacy and tolerability attributes that patients desire. ⋯ Composite efficacy-plus-tolerability endpoints may be useful for facilitating comparisons between treatments.