Nuclear medicine communications
-
Clinical Trial Controlled Clinical Trial
Quantification of extracorporeal white cell and platelet deposition in cardiopulmonary bypass: comparison of membrane and bubble oxygenators.
Cardiopulmonary bypass is known to activate both white cells and platelets. The aim of this study was to investigate whether the use of bubble and membrane oxygenators results in different degrees of deposition in the filter and oxygenator of the bypass circuit. Dual-isotope imaging techniques were employed, with white cells labelled with 99Tcm and platelets with 111In, and with subsequent imaging of the filters and oxygenators on a gamma camera fitted with a medium-energy, parallel-hole collimator, relative to a known standard. ⋯ The striking feature of the data is the non-normal distribution of the deposition in both types of oxygenator. This study demonstrated that both white cell and platelet deposition in the cardiopulmonary bypass circuit can be quantified using radiolabelled cells. No differences in oxygenator or filter deposition were found in patients randomly allocated to membrane or bubble oxygenation.