Nuclear medicine communications
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Comparative Study
Hypoxia imaging of patients with acute myocardial infarction by using dual isotopes of 201Tl and 99mTc-HL91.
To evaluate the myocardial ischaemia/viability in patients with acute myocardial infarction (AMI) using the ischaemia-avid agent (99m)Tc-HL91. ⋯ Myocardial uptake of (99m)Tc-HL91 is perfusion-dependent as well as ischaemia dependent. (99m)Tc-HL91 hypoxia imaging alone is not sufficient to identify ischaemic/viable myocardium. Dual-isotope imaging with (201)Tl and (99m)Tc-HL91 can characterize the myocardium into normal, ischaemic/viable and necrotic (scarred) myocardium.
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Quantifying hemispheric cerebral blood flow (CBF) may improve diagnostic accuracy when combined with perfusion SPECT. ⋯ Routine quantification of mean CBF by HMPAO-RNA is a simple and reproducible method which can be easily added to the standard brain perfusion SPECT without additional cost or increasing patient's radiation burden. Combined with regional perfusion it provides an additional tool for the aetiological classification of dementia.