Nuclear medicine communications
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Multicenter Study Clinical Trial
Assessment of left ventricular contractile reserve by means of myocardial perfusion-gated SPECT in patients with early systolic dysfunction after acute myocardial infarction and in patients with chronic ischemic cardiomyopathy.
In patients with depressed systolic function after recent acute myocardial infarction (AMI), improvement of global left ventricular (LV) systolic function using low-dose dobutamine (LDD) may be influenced by factors different from those observed in patients with chronic ischemic cardiomyopathy (CIC). The aim of this study was to analyze, by means of myocardial perfusion-gated single photon emission computed tomography, segmental thickening (STh), LV volumes and ejection fraction (EF), at baseline and during LDD infusion in patients with systolic dysfunction early after AMI, and compare these results with those in patients with CIC. ⋯ Improvement of LVEF with LDD in patients with systolic dysfunction early after AMI depended essentially on contractile reserve in segments with severely impaired baseline thickening, whereas in patients with CIC it depended on overall LV contractile reserve and the presence of less ventricular remodeling.
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Comparative Study
Comparison of 123I-MIBG SPECT-CT and 18F-DOPA PET-CT in the evaluation of patients with known or suspected recurrent paraganglioma.
Detection of recurrent disease is essential for treatment planning in patients with paraganglioma. The aim of this study was to compare 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy [whole-body and single-photon emission computed tomography (SPECT) computed tomography (CT) scanning] and fluorine-18-L-dihydroxyphenylalanine positron emission tomography CT (18F-DOPA PET-CT) in the re-staging of patients with known or suspected recurrent paraganglioma. ⋯ These data support the superiority of 18F-DOPA PET-CT over 123I-MIBG scintigraphy to assess disease extension in patients with recurrent paraganglioma; however, in cases with inoperable disease, 123I-MIBG maintains a unique role in allowing the selection of patients suitable for 123I-MIBG therapy.