Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
-
Graefes Arch. Clin. Exp. Ophthalmol. · Apr 2012
Comparative StudyMorphologic and functional association of retinal layers beneath the epiretinal membrane with spectral-domain optical coherence tomography in eyes without photoreceptor abnormality.
To access the differential thickening of retinal layers in the epiretinal membrane (ERM) and to determine their correlation with visual acuity. ⋯ Idiopathic ERM affects the volume of all retinal layers. Inner retina had the most variability of thickness and is strongly associated with visual acuity changes in the case of intact photoreceptor layer.
-
Graefes Arch. Clin. Exp. Ophthalmol. · Apr 2012
Case ReportsAdverse events associated with intraocular injections of bevacizumab in eyes with neovascular glaucoma.
Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), has been reported to cause rapid regression of anterior segment neovascularization in eyes with neovascular glaucoma when administered intraocularly. Several studies have reported the safety profile of intravitreal injections of bevacizumab in patients with various retinal pathologies. We investigated the occurrence of adverse events associated with intraocular bevacizumab injections in patients with neovascular glaucoma. ⋯ Central retinal artery occlusion may be a relatively common complication following intraocular injection of anti-VEGF agents in patients with neovascular glaucoma, particularly when it was associated with ocular ischemic syndrome. Since visual prognosis of central retinal artery occlusions is usually poor, intraocular injection of anti-VEGF agents should be performed with thoughtful consideration of the risks and benefits of the treatment, and with a strict follow-up examination, especially in high-risk patients.