Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
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J. Oral Maxillofac. Surg. · Nov 1998
Randomized Controlled Trial Comparative Study Clinical TrialSubcutaneous administration of midazolam: a comparison of the Bioject jet injector with the conventional syringe and needle.
The purpose of this study was to compare jet injection to a syringe and needle in terms of the difference in discomfort and pharmacokinetics after the subcutaneous administration of midazolam. ⋯ The results of the study show that the Biojector 2000 is a needle-free injection system that can be used for the administration of a premedicant before induction of anesthesia. It has several advantages, including the potential reduction of anxiety associated with the "fear of needles" and occupational injuries.
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J. Oral Maxillofac. Surg. · Nov 1998
Comparative StudyEffect of intra-articular versus systemic anti-inflammatory drugs in a rabbit model of temporomandibular joint inflammation.
In an attempt to better understand the time course of inflammatory mediator production or release in inflammatory joint disease, a rabbit model of acute temporomandibular joint (TMJ) inflammation was established. This model was used to evaluate the effects of specific anti-inflammatory agents administered either systemically (intraperitoneal, IP) or locally (intra-articular, IA) on the modulation of in vivo tissue levels of two prototypic inflammatory mediators, prostaglandin E2 (PGE2) and bradykinin (BK). ⋯ This study shows that the rabbit model of TMJ inflammation, with concurrent collection of iBK and iPGE2 via microdialysis, is a reproducible and reliable method to investigate the time course of inflammatory mediator release and their modulation by either the local or systemic administration of anti-inflammatory medications.
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The purpose of this study was to describe the imaging characteristics of posterior disc displacement of the temporomandibular joint (TMJ). ⋯ Posterior disc displacement of the TMJ is rare but has probably been overlooked in the past because of a lack of well-defined imaging characteristics.