American journal of clinical oncology
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Am. J. Clin. Oncol. · Aug 2009
ReviewProphylaxis and treatment of venous thromboembolism in cancer patients: a review.
Thromboprophylaxis is underused in patients with cancer, despite the fact that malignancy is a serious risk factor for venous thromboembolism in this population. Major medical guidelines, including those published recently by the American College of Chest Physicians, the American Society of Clinical Oncology, and the National Comprehensive Cancer Network, recommend routine thromboprophylaxis for patients with cancer under certain situations. This review describes current recommendations for primary and secondary prophylaxis in patients with cancer.
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Am. J. Clin. Oncol. · Aug 2009
Comparative StudyExcellent results from high dose rate brachytherapy and external beam for prostate cancer are not improved by androgen deprivation.
Prostate cancer patients treated with high dose rate brachytherapy and external beam radiation therapy were stratified by risk group for analysis to determine whether androgen deprivation therapy (ADT) affected outcome. ⋯ high dose rate brachytherapy and external beam radiation therapy resulted in high rates of local control, PSA progression-free survival, distant metastasis free survival, and cause-specific survival in all risk groups. Improved outcome from the use of androgen deprivation was not observed.
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Am. J. Clin. Oncol. · Aug 2009
Squamous cell carcinoma of the external auditory canal: long-term clinical outcomes using surgery and external-beam radiotherapy.
Squamous cell carcinoma (SCCA) of the external auditory canal (EAC) is often treated with a combination of surgery and radiotherapy (RT) to optimize the chance of achieving locoregional control. This retrospective review describes a 27-year experience of treating these tumors at the University of Florida. ⋯ Patients with early stage disease achieved better local control, locoregional control, and cause-specific survival than those with advanced tumors. Less than half of the patients (13 of 30; 43%) were cured without significant complications, suggesting a suboptimal therapeutic ratio, using current treatment methods.
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Am. J. Clin. Oncol. · Aug 2009
Comparative StudyEconomic analysis of radiation therapy oncology group 97-14: multiple versus single fraction radiation treatment of patients with bone metastases.
Radiation Therapy Oncology Group 97-14 concluded that a single fraction of radiation was as effective in relieving pain as multiple fractions in the treatment of patients with bone metastases. A statistically significant higher retreatment rate, however, was noted in patients undergoing a single fraction treatment. The purpose of the analysis was to determine whether multiple fraction treatment is cost-effective in treating patients with bone metastasis, by preventing further retreatment. ⋯ Single fraction treatment was the less expensive treatment in the treatment of patients with bone metastasis treated on Radiation Therapy Oncology Group 97-14.
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Am. J. Clin. Oncol. · Aug 2009
Permanent interstitial reirradiation with 198Au as salvage therapy for low volume recurrent gynecologic malignancies: a single institution experience.
To examine the Indiana University experience using 198Au permanent interstitial reirradiation (198Au-IRI) in the treatment of selected patients with recurrent gynecologic malignancies. ⋯ 198Au-IRI is a safe, cost-effective, and reasonably efficacious method for controlling locally recurrent, low-volume, well-selected gynecologic malignancies, and treated with previous full-dose radiotherapy. It represents a reasonable potential therapeutic option in the salvage setting in patients who meet these criteria, particularly in women who are not candidates for or are unwilling to undergo radical salvage surgery.