American journal of clinical oncology
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Am. J. Clin. Oncol. · Dec 2010
Comparative StudyBrain metastases from melanoma: is there a role for concurrent temozolomide in addition to whole brain radiation therapy?
This study was performed to evaluate the addition of temozolomide (TMZ) to whole brain radiotherapy (WBRT) for brain metastases from melanoma. ⋯ Patients did not appear to benefit from the addition of TMZ to WBRT for the treatment of their brain metastases. Further improvements in outcome will require research to discover more effective systemic therapy and RT techniques.