American journal of clinical oncology
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Am. J. Clin. Oncol. · Dec 1983
Randomized Controlled Trial Clinical TrialFast neutron radiation therapy for glioblastoma multiforme. Results of an RTOG study.
Between January 1977 and September 1980, 166 patients were entered on a RTOG protocol comparing neutron-boost radiotherapy with standard treatment for patients with glioblastomas. Eighty-three patients were randomized to receive a neutron boost and 83 to receive a photon boost after 50 Gy photon, whole-brain irradiation. ⋯ The difference is not statistically significant. Autopsies revealed actively growing persistent tumor in all photon-treated patients compared to no evidence of actively growing tumor in the majority of neutron-treated patients.
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5-Fluorouracil (5-Fu) was administered by a constant venous infusion schedule at a dose of 300 mg/m2/d for 30-180 days. The dose schedule was associated with minimal toxicity in 32 patients with gastrointestinal cancer treated by employing a portable infusion pump for ambulatory drug delivery. ⋯ The responses according to tumor type were as follows: 1/1 gastric cancer; 1/2 hepatoma; and 4/18 colon cancer. The superiority of this new treatment schedule for 5-Fu will need to be established by prospective randomized clinical trials.
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Eighteen of the patients randomized for treatment according to the first and second National Wilms' Tumor Studies have developed clinically evident tumor in the contralateral kidney subsequent to the initial diagnosis. Only seven of 18 had an adequate exploration of the opposite kidney during the initial surgery and of these seven, four had abnormal findings. ⋯ While metachronous Wilms' tumors are an unusual occurrence, the prognosis is ominous with only seven of 18 surviving free of disease. The outlook might be improved with adequate attention to the surgical and histologic details during the initial diagnostic procedures.