Clinical rheumatology
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Clinical rheumatology · Feb 2011
Randomized Controlled TrialA long-term prospective randomized controlled study of non-specific interstitial pneumonia (NSIP) treatment in scleroderma.
The association of cyclophosphamide (CYC) and prednisone (PRED) for the treatment of lung fibrosis in systemic sclerosis (SSc) was only evaluated in uncontrolled studies, although in idiopathic interstitial lung disease (ILD) this association seems to be beneficial in patients with non-specific interstitial pneumonia (NSIP). ⋯ CYC was effective to stabilize lung function parameters in NSIP lung pattern of SSc disease for 3 years after the end of a 1-year therapy.