Clinical rheumatology
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Clinical rheumatology · Sep 2012
Amisulpride in the treatment of fibromyalgia: an uncontrolled study.
Some antipsychotics, including amisulpride, have shown to be effective in the treatment of various painful conditions, lessening pain as well as symptoms of anxiety and/or depression. In this open-label, 12-week study, we explored the efficacy and tolerability of amisulpride in patients with fibromyalgia. We recruited 40 patients, 1 male and 39 females, aged 46.2 ± 6.8 years, who met the ACR criteria for fibromyalgia and had a score equal to or greater than 4 in the pain severity item of the Fibromyalgia Impact Questionnaire (FIQ). ⋯ Twenty-six patients either withdrew from the study, mainly due to adverse reactions, or were lost to follow-up (n = 11, 27.5 %, for each category). Despite its promising results in some chronic painful conditions and in a related illness, such as chronic fatigue syndrome, amisulpride does not seem to provide any benefit to patients with fibromyalgia. Amisulpride was poorly tolerated by our participants.