Journal of pediatric gastroenterology and nutrition
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J. Pediatr. Gastroenterol. Nutr. · Oct 2011
Cortisol diurnal rhythm and stress reactivity in constipation and abdominal pain: the Generation R Study.
The aim of this study was to assess whether diurnal cortisol rhythm and cortisol stress reactivity were associated with functional constipation and abdominal pain in infancy. ⋯ Our results suggest that cortisol as a marker for stress does not play a major role in functional constipation or abdominal pain in infancy.
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J. Pediatr. Gastroenterol. Nutr. · Oct 2011
Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouse.
The intestinal mucosal barrier protects the body from the large numbers of microbes that inhabit the intestines and the molecules they release. Intestinal barrier function is impaired in humans with cystic fibrosis (CF), including reduced activity of the lipopolysaccharide-detoxifying enzyme intestinal alkaline phosphatase (IAP) and increased permeability. The objective of this study was to determine the suitability of using the CF mouse to investigate intestinal barrier function, and whether interventions that are beneficial for the CF mouse intestinal phenotype (antibiotics or laxative), would improve barrier function. Also tested were the effects of exogenous IAP administration. ⋯ The CF mouse intestine has impaired mucosal barrier function, similar to human CF. Interventions that improve other aspects of the CF intestinal phenotype (antibiotics and laxative) also increase IAP activity and decrease intestinal permeability in CF mice. Exogenous IAP improve permeability and strongly reduce bacterial overgrowth in CF mice, suggesting this may be a useful therapy for CF.
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J. Pediatr. Gastroenterol. Nutr. · Aug 2011
Randomized Controlled Trial Comparative StudyMetoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis.
To compare the efficacy and safety of ondansetron versus less expensive metoclopramide in the treatment of children with persistent vomiting with acute gastroenteritis. ⋯ In the sample size tested, intravenous metoclopramide therapy did not differ from ondansetron in the treatment of persistent vomiting for children with gastroenteritis admitted for intravenous fluid hydration.
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J. Pediatr. Gastroenterol. Nutr. · Jul 2011
Comparative StudyUse of deamidated gliadin peptide antibodies to monitor diet compliance in childhood celiac disease.
The aim of this study was to evaluate performance of serum antibodies against deamidated gliadin peptides (a-DGPs) in detecting compliance with gluten-free diet (GFD) in children with celiac disease (CD). ⋯ Both a-DGPs showed higher sensitivity than anti-tTG IgA and AGA IgA in monitoring compliance with GFD, but a-DGP IgA+G seemed to perform better. a-DGPs did not outperform anti-tTG IgA for CD screening.