Journal of pediatric gastroenterology and nutrition
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J. Pediatr. Gastroenterol. Nutr. · Jul 2005
Randomized Controlled Trial Clinical TrialA randomized controlled trial of enteral glutamine supplementation in very low birth weight infants: plasma amino acid concentrations.
Glutamine depletion has negative effects on the functional integrity of the gut and leads to immunosuppression. Very low birth weight (VLBW) infants are susceptible to glutamine depletion, as enteral nutrition is limited in the first weeks of life. Enteral glutamine supplementation may have a positive effect on feeding tolerance, infectious morbidity and short-term outcome. The aim of the study was to determine the effect of enteral glutamine supplementation on plasma amino acid concentrations, reflecting one aspect of safety of enteral glutamine supplementation in VLBW infants. ⋯ Enteral glutamine supplementation in VLBW infants does not alter plasma concentrations of glutamine, glutamate or other amino acids. Enteral supplementation in a dose of 0.3 g/kg per day seems safe in VLBW infants.
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J. Pediatr. Gastroenterol. Nutr. · May 2005
Etiology, outcome and prognostic indicators of childhood fulminant hepatic failure in the United kingdom.
To study the etiology, outcome and prognostic indicators in children with fulminant hepatic failure in the United Kingdom. ⋯ Children with fulminant hepatic failure with severe coagulopathy, lower alanine aminotransferase on admission and prolonged duration of illness before the onset of hepatic encephalopathy are more likely to require liver transplantation. Early referral to a specialized center for consideration of liver transplantation is vital.