Thrombosis research
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Thrombosis research · Nov 2002
Resistance to aspirin in vitro at rest and during exercise in patients with angiographically proven coronary artery disease.
Acetylsalicylic acid, or aspirin, is widely used in secondary prevention of coronary artery diseases, but the inhibition of platelet aggregation is not uniform in all individuals. ⋯ Aspirin resistance is detected, at rest, in 20% of our patients with stable coronary artery disease. Aspirin treatment does not seem to protect against exercise-induced platelet activation in 22% of such patients, despite aspirin sensitivity at rest.