Thrombosis research
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Thrombosis research · Sep 2011
Clinical TrialIs a V/Q scan based algorithm correctly used to diagnose acute pulmonary embolism? A daily practice survey.
Diagnostic flow-charts for pulmonary embolism (PE) are widely implemented in the management of PE. A major drawback of a diagnostic PE algorithm is the use of several consecutive tests, which may be challenging in daily clinical practice. ⋯ A complex diagnostic algorithm for diagnosing PE is often not followed properly. This improper use of an algorithm could lead to a potential delay of establishing or excluding PE, a delay of therapy and/or unnecessary treatment. More simple algorithms could resolve this diagnostic management dilemma.
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Thrombosis research · Sep 2011
Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery.
Cardiac surgery performed on cardio-pulmonary bypass (CPB) may be complicated by coagulopathy and bleeding. This prospective observational study investigated the CPB-induced changes in thrombin generation, fibrin formation, and in the platelet component of the whole blood clot elasticity. The effects of haemostatic therapy with fresh frozen plasma (FFP) and platelet concentrate on these parameters were also evaluated. ⋯ Fibrin formation is more impaired than thrombin generation and the platelet component of the whole blood clot immediately after cardiopulmonary bypass.