Thrombosis research
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Thrombosis research · Oct 2018
Complement component consumption in sepsis correlates better with hemostatic system parameters than with inflammatory biomarkers.
The aim of this study was to investigate the role of C3 and C4 complement components in prediction of sepsis outcome. The secondary aim was to determine relationship between complement components and other inflammatory parameters, and parameters of hemostasis. ⋯ In septic patients with poorer outcome, a significant depletion of the complement system was observed. Concentrations of complement components demonstrated stronger correlations with coagulation parameters than with inflammatory biomarkers.
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Thrombosis research · Oct 2018
Direct oral anticoagulants in patients with liver cirrhosis: A systematic review.
Anticoagulant treatment in patients with liver cirrhosis is challenging. The aim of this systematic review was to evaluate clinical outcomes of direct oral anticoagulant (DOAC) therapy in cirrhosis patients. ⋯ There is paucity of data on the efficacy and safety of DOACs in patients with cirrhosis. This analysis suggests that DOACs may be effective and safe for treatment of VTE, SVT, and AF in these patients.
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Thrombosis research · Oct 2018
Meta AnalysisEfficacy and safety of anticoagulant agents in patients with venous thromboembolism and cancer: A network meta-analysis.
Low-molecular-weight heparins (LMWHs) are the recommended treatment for cancer-associated venous thrombosis (CAT). Recent evidences suggest a role for direct-acting oral anticoagulants (DOACs) in this clinical setting. ⋯ In patients with CAT, DOACs showed a good efficacy and safety profile compared to other anticoagulants and is candidates to be an alternative to LMWHs.
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Thrombosis research · Oct 2018
Multicenter StudyDeep-vein thrombosis in Europe - Burden of illness in relationship to healthcare resource utilization and return to work.
Deep-vein thrombosis (DVT) forms a major healthcare burden in Europe, but exact estimates concerning the economic burden on society are lacking. This study reports results from the PREFER in VTE study concerning resource utilization and absence from work in DVT patients. ⋯ Medical treatment of DVT differed between patients with active cancer and those without. Post-VTE or VTE-related resource utilization differs remarkably between countries. Work-loss seems high, but questions may be raised concerning the causality due to the presence of co-morbidities.