Thrombosis research
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Thrombosis research · Oct 2011
New recommendations for thromboelastography reference ranges for pregnant women.
The target of this study was to compare thromboelastography coagulation parameters in pregnant and non-pregnant women. If appropriate, we would propose recommendations for new reference ranges for pregnant women in their third trimester. ⋯ It may not be suitable to use the same reference ranges for pregnant women as for the general population. Therefore, we suggest new reference limits for thromboelastography in pregnant women.
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Thrombosis research · Oct 2011
Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation.
The therapeutic potential of a hemostatic agent can be assessed by investigating its effects on the quantitative parameters of thrombin generation. For recombinant activated factor VII (rFVIIa)--a promising hemostasis-inducing biologic--experimental studies addressing its effects on thrombin generation yielded disparate results. To elucidate the inherent ability of rFVIIa to modulate thrombin production, it is necessary to identify rFVIIa-induced effects that are compatible with the available biochemical knowledge about thrombin generation mechanisms. ⋯ rFVIIa modulates thrombin generation primarily by accelerating the process, without significantly affecting the total amount of generated thrombin.
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Thrombosis research · Sep 2011
Clinical TrialIs a V/Q scan based algorithm correctly used to diagnose acute pulmonary embolism? A daily practice survey.
Diagnostic flow-charts for pulmonary embolism (PE) are widely implemented in the management of PE. A major drawback of a diagnostic PE algorithm is the use of several consecutive tests, which may be challenging in daily clinical practice. ⋯ A complex diagnostic algorithm for diagnosing PE is often not followed properly. This improper use of an algorithm could lead to a potential delay of establishing or excluding PE, a delay of therapy and/or unnecessary treatment. More simple algorithms could resolve this diagnostic management dilemma.
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Thrombosis research · Sep 2011
Fibrin formation is more impaired than thrombin generation and platelets immediately following cardiac surgery.
Cardiac surgery performed on cardio-pulmonary bypass (CPB) may be complicated by coagulopathy and bleeding. This prospective observational study investigated the CPB-induced changes in thrombin generation, fibrin formation, and in the platelet component of the whole blood clot elasticity. The effects of haemostatic therapy with fresh frozen plasma (FFP) and platelet concentrate on these parameters were also evaluated. ⋯ Fibrin formation is more impaired than thrombin generation and the platelet component of the whole blood clot immediately after cardiopulmonary bypass.
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Thrombosis research · Jul 2011
Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma.
In an effort to administer life-saving transfusions quickly, some trauma centers maintain thawed plasma (TP). According to AABB, TP is approved for transfusion for up to five days when stored at 1-6° C. However, the alterations in microparticles (MP) contained in the plasma, which are an integral component of plasma's hemostatic capacity, are not well characterized. We report on MP changes in TP between its initial thaw (FFP-0) and five days (FFP-5) of storage. ⋯ Decline in MP with storage contributes to FFP-5's reduced ability to provide the hemostatic potential exhibited by FFP-0, suggesting the presence of platelet MPs in freshly TP may be beneficial and protective in the initial treatment of hemorrhage.