Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
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Acta Otorhinolaryngol Ital · Dec 2010
Randomized Controlled Trial Comparative StudyComparing the effects of desflurane and isoflurane on middle ear pressure.
The aim of this study was to determine middle ear pressure changes during the operation performed under anaesthesia induced by isoflurane or desflurane. This was a prospective, case-control study. A total of 38 children with no middle ear pathology scheduled for inguinal hernia surgery were included in the study. ⋯ Increase in the mean middle ear pressure values at the 5(th) and 10(th) minute of the operation was significant different between both groups (2.84 and 5.80 daPa for isoflurane; 59.06 and 72.81 daPa for desflurane; p ≤ 0.05). Desflurane is more increased than isoflurane on intra-tympanic pressure and isoflurane may be used more safely than desflurane in middle ear operations. The low effect of isoflurane on intra-tympanic pressure can be explained by the high blood/gas partition coefficient compared to desflurane.